Wanwimolruk S, Pratt E L, Denton J R, Chalcroft S C, Barron P A, Broughton J R
School of Pharmacy, University of Otago, Dunedin, New Zealand.
Pharmacogenetics. 1995 Aug;5(4):193-8. doi: 10.1097/00008571-199508000-00002.
The genetic oxidation polymorphisms of debrisoquine and proguanil were studied in a New Zealand Maori population. A bimodal distribution was observed in the 0-4 h urinary debrisoquine/4-hydroxydebrisoquine metabolic ratio. Of 101 Maori subjects phenotyped, five subjects (5%) were identified as poor metabolizers of debrisoquine, according to criteria established in studies of Caucasian populations. The prevalence of the debrisoquine poor metabolizer phenotype in the Maori appears to be similar to that reported for the Caucasian populations, but higher than that found in Asian (non-Caucasian) populations. The distribution of proguanil:cycloguanil (PG:CG) ratios obtained from 43 Maori subjects was highly skewed. Using a PG:CG ratio of 10 as the cut-off point, three Maori subjects (7%) were classified as poor metabolizers of proguanil. The incidence of the poor metabolizer phenotype of proguanil oxidation of 7% seems to be higher in Maori compared with Caucasian populations, but this is lower than the usual ranges (15-35%) reported in Asian populations.
在新西兰毛利人群体中研究了异喹胍和氯胍的遗传氧化多态性。在0至4小时尿液中异喹胍/4-羟基异喹胍代谢比值中观察到双峰分布。在101名已进行表型分析的毛利受试者中，根据在白种人群体研究中确立的标准，有5名受试者（5%）被鉴定为异喹胍慢代谢者。毛利人群体中异喹胍慢代谢者表型的患病率似乎与白种人群体中报告的相似，但高于亚洲（非白种人）群体中发现的患病率。从43名毛利受试者获得的氯胍：环氯胍（PG:CG）比值分布高度偏态。以PG:CG比值10作为分界点，3名毛利受试者（7%）被归类为氯胍慢代谢者。与白种人群体相比，毛利人群体中氯胍氧化慢代谢者表型的发生率7%似乎更高，但低于亚洲人群体中报告的通常范围（15 - 35%）。
