一氧化氮对胃损伤的保护作用以及氟比洛芬及其硝基衍生物硝氟比洛芬对胃诱导型一氧化氮合酶表达的抑制作用。
Protective effect of NO on gastric lesions and inhibition of expression of gastric inducible NOS by flurbiprofen and its nitro-derivative, nitroflurbiprofen.
作者信息
Mariotto S, Menegazzi M, Carcereri de Prati A, Cuzzolin L, Adami A, Suzuki H, Benoni G
机构信息
Istituto di Chimica Biologica, Università di Verona, Italy.
出版信息
Br J Pharmacol. 1995 Sep;116(2):1713-4. doi: 10.1111/j.1476-5381.1995.tb16650.x.
Abstract
Nitroflurbiprofen (NFP) causes significantly less gastric lesions than flurbiprofen (FP), probably because of its capacity to release nitric oxide (NO) in the stomach. Lipopolysaccharide (LPS), which induces the expression of an inducible type of NO synthase (iNOS) in rat stomach, also reduces gastric mucosal damage elicited by FP. Furthermore, both FP and NFP decrease significantly the amount of mRNA encoding iNOS induced by LPS in the stomach. The inhibitory effect of NFP seems to be due at least in part to its ability to release NO.
摘要
氟比洛芬酯（NFP）引起的胃部损伤明显少于氟比洛芬（FP），这可能是因为它能够在胃中释放一氧化氮（NO）。脂多糖（LPS）可诱导大鼠胃中诱导型一氧化氮合酶（iNOS）的表达，它也能减轻FP引起的胃黏膜损伤。此外，FP和NFP均能显著减少LPS诱导的胃中iNOS编码mRNA的量。NFP的抑制作用似乎至少部分归因于其释放NO的能力。
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