新型非甾体抗炎药氟比洛芬对大鼠中性粒细胞中诱导型一氧化氮合酶表达的影响。
Effect of a new non-steroidal anti-inflammatory drug, nitroflurbiprofen, on the expression of inducible nitric oxide synthase in rat neutrophils.
作者信息
Mariotto S, Cuzzolin L, Adami A, Del Soldato P, Suzuki H, Benoni G
机构信息
Istituto di Chimica Biologica, Università di Verona, Italy.
出版信息
Br J Pharmacol. 1995 May;115(2):225-6. doi: 10.1111/j.1476-5381.1995.tb15867.x.
Abstract
The effects of a non-steroidal anti-inflammatory drug, flurbiprofen, and its nitro-derivative, nitroflurbiprofen, on inducible nitric oxide synthase in rat neutrophils were examined. Nitroflurbiprofen was shown to inhibit nitric oxide synthase induction caused by lipopolysaccharide administration, while flurbiprofen had no effect on nitric oxide synthase induction. This inhibitory action may be ascribed to nitric oxide released from nitroflurbiprofen.
摘要
研究了非甾体抗炎药氟比洛芬及其硝基衍生物硝氟比洛芬对大鼠中性粒细胞中诱导型一氧化氮合酶的影响。结果表明，硝氟比洛芬可抑制脂多糖给药引起的一氧化氮合酶诱导，而氟比洛芬对一氧化氮合酶诱导无影响。这种抑制作用可能归因于硝氟比洛芬释放的一氧化氮。
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