硝普钠对大鼠中性粒细胞中诱导型一氧化氮合酶表达的抑制作用。
Inhibition by sodium nitroprusside of the expression of inducible nitric oxide synthase in rat neutrophils.
作者信息
Mariotto S, Cuzzolin L, Adami A, Del Soldato P, Suzuki H, Benoni G
机构信息
Istituto di Chimica Biologica, Università di Verona, Italy.
出版信息
Br J Pharmacol. 1995 Mar;114(6):1105-6. doi: 10.1111/j.1476-5381.1995.tb13320.x.
Abstract
A well-known nitric oxide (NO)-releasing compound, sodium nitroprusside (SNP), decreases in a dose-dependent manner NO synthase (NOS) activity induced in rat neutrophils by treatment with lipopolysaccharide (LPS). This inhibitory action of SNP seems not to be due to its direct effect on the enzyme activity. The strong nitrosonium ion (NO+) character of SNP could be responsible for its inhibition of NOS induction in neutrophils.
摘要
一种著名的释放一氧化氮（NO）的化合物硝普钠（SNP），能以剂量依赖的方式降低脂多糖（LPS）处理诱导的大鼠中性粒细胞中的一氧化氮合酶（NOS）活性。SNP的这种抑制作用似乎并非因其对酶活性的直接影响。SNP的强亚硝鎓离子（NO⁺）特性可能是其抑制中性粒细胞中NOS诱导的原因。
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