Gardiner S M, Kemp P A, March J E, Bennett T
Department of Physiology and Pharmacology, Medical School, Queen's Medical Centre, Nottingham.
Br J Pharmacol. 1995 Sep;116(2):1718-9. doi: 10.1111/j.1476-5381.1995.tb16652.x.
In conscious, chronically-instrumented rats, the non-selective endothelin antagonist, SB 209670 (10 micrograms kg-1 min-1), caused marked enhancement of the fall in mean arterial blood pressure during infusion of lipopolysaccharide (LPS) for 24 h (LPS alone = -6 +/- 3 mmHg; LPS+SB 209670 = -30 +/- 2 mmHg). This effect was accompanied by a conversion of the mesenteric vasoconstriction to a substantial mesenteric vasodilatation and an augmentation of the hindquarters vasodilatation, seen with LPS alone. Notably, the marked renal hyperaemic vasodilatation during LPS infusion was not affected significantly by SB 209670. These results indicate that endothelin, directly and/or indirectly, plays a pivotal role in the cardiovascular sequelae of endotoxaemia in conscious rats, and prevents marked hypotension, particularly by opposing mesenteric vasodilatation.
在清醒的、长期植入仪器的大鼠中，非选择性内皮素拮抗剂SB 209670（10微克/千克/分钟）在输注脂多糖（LPS）24小时期间，导致平均动脉血压下降显著增强（单独使用LPS时=-6±3毫米汞柱；LPS+SB 209670时=-30±2毫米汞柱）。这种效应伴随着肠系膜血管收缩转变为显著的肠系膜血管舒张，以及后肢血管舒张增强，单独使用LPS时可见后肢血管舒张。值得注意的是，LPS输注期间显著的肾充血性血管舒张并未受到SB 209670的显著影响。这些结果表明，内皮素直接和/或间接在清醒大鼠内毒素血症的心血管后遗症中起关键作用，并预防显著的低血压，特别是通过对抗肠系膜血管舒张来实现。
