使膜发挥作用：双层膜融合中的结构中间体

Bending membranes to the task: structural intermediates in bilayer fusion.

作者信息

Chernomordik L V, Zimmerberg J

机构信息

Laboratory of Theoretical and Physical Biology, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892-1855, USA.

出版信息

Curr Opin Struct Biol. 1995 Aug;5(4):541-7. doi: 10.1016/0959-440x(95)80041-7.

DOI:10.1016/0959-440x(95)80041-7

PMID:8528771

Abstract

Merger of lipid bilayers plays a central role in diverse biological fusion reactions. Recent studies suggest that different membrane fusion systems, including fusion of purely lipid bilayers, involve formation of similar stalk-type intermediates--highly bent (net negative curvature) and transient lipidic connections between fusing membranes.

摘要

脂质双层的融合在多种生物融合反应中起着核心作用。最近的研究表明，不同的膜融合系统，包括纯脂质双层的融合，都涉及形成类似茎状的中间体——高度弯曲（净负曲率）以及融合膜之间短暂的脂质连接。