氰酸盐诱导的高血红蛋白-氧亲和力豚鼠和大鼠对严重急性缺氧的通气反应。

Ventilatory response to severe acute hypoxia in guinea-pigs and rats with high hemoglobin-oxygen affinity induced by cyanate.

作者信息

Rivera M, León-Velarde F, Huicho L, Monge C

机构信息

Departamento de Ciencias Fisiológicas, Universidad Peruana Cayetano Heredia, Lima.

出版信息

Comp Biochem Physiol A Physiol. 1994 Nov;109(3):675-80. doi: 10.1016/0300-9629(94)90209-7.

DOI:10.1016/0300-9629(94)90209-7

PMID:8529009

Abstract

Baseline ventilation, hemoglobin concentration (Hb) and P50 were significantly lower in guinea-pigs than in rats. Chronic sodium cyanate (NaOCN) administration did not significantly increase hemoglobin concentration in either guinea-pigs or rats. It decreased the P50 significantly less in guinea-pigs than in rats. The high Hb-O2 affinity experimentally induced did not modify the hypoxic ventilatory response (HVR) of guinea-pigs and rats. At the same level of acute hypoxia, HVR was significantly lower in NaOCN guinea-pigs than in NaOCN rats. Guinea-pigs, genotypically adapted animals to high altitude, displayed relatively minor ventilatory and Hb-O2 affinity changes to NaOCN, and a relatively minor HVR to acute hypoxia. They probably use tissue and biochemical adaptive mechanisms, in addition to their limited extracellular responses to successfully tolerate ambient hypoxia.

摘要

豚鼠的基线通气、血红蛋白浓度（Hb）和P50显著低于大鼠。长期给予氰酸钠（NaOCN）对豚鼠和大鼠的血红蛋白浓度均无显著增加作用。它使豚鼠P50的降低幅度明显小于大鼠。实验诱导的高Hb-O₂亲和力并未改变豚鼠和大鼠的低氧通气反应（HVR）。在相同程度的急性低氧水平下，NaOCN处理的豚鼠的HVR显著低于NaOCN处理的大鼠。豚鼠是在基因上适应高海拔的动物，对NaOCN表现出相对较小的通气和Hb-O₂亲和力变化，以及对急性低氧相对较小的HVR。除了有限的细胞外反应外，它们可能还利用组织和生化适应机制来成功耐受环境低氧。