Ricci G, Colombo C, Ghiazza B, Porta C, Moroni M, Illeni M T
2nd Geriatric Division, Azienda Ospedale San Gerardo, Monza, Milan, Italy.
Cancer Lett. 1995 Nov 27;98(1):121-5.
We have evaluated the frequency of HLA class I and II antigens in 205 Italian patients with hepatocellular carcinoma (HCC) and 749 blood donors (controls). Moreover, we have looked for correlations between HLA antigen frequencies and HBV and/or HCV infections in HCC patients. We found great differences in HLA antigen frequencies considering only two groups: HCC patients and controls. The polymorphism is smaller when we consider the different groups of HCC patients in regard to the previous viral infections (HBV and/or HCV). The most interesting finding is the higher frequency of Cw7, B8 and DR3 in almost all groups of HCC patients. It is well known, that the HLA A1, Cw7, B8, DR3 antigen haplotype is associated with a rapid decline of CD4 cells, and HLA B8, DR3 positive subjects may display some changes in immune parameters and are prone to develop several immunological diseases. Thus HCC might be the result of a lower sensitivity (genetically given) to mitogenic stimuli of HBV and HCV.
我们评估了205例意大利肝细胞癌（HCC）患者和749名献血者（对照）中HLA I类和II类抗原的频率。此外，我们还探寻了HCC患者中HLA抗原频率与HBV和/或HCV感染之间的相关性。仅考虑HCC患者和对照这两组时，我们发现HLA抗原频率存在很大差异。当我们根据先前的病毒感染（HBV和/或HCV）来考虑不同组的HCC患者时，多态性较小。最有趣的发现是，几乎所有组的HCC患者中Cw7、B8和DR3的频率较高。众所周知，HLA A1、Cw7、B8、DR3抗原单倍型与CD4细胞的快速下降有关，HLA B8、DR3阳性受试者可能在免疫参数上有一些变化，并且容易患上几种免疫性疾病。因此，HCC可能是对HBV和HCV促有丝分裂刺激的敏感性较低（由基因决定）的结果。
