Dean J W, Culbertson K C, D'Angelo A M
Department of Periodontology, University of Tennessee, College of Dentistry, Memphis 38163, USA.
Int J Oral Maxillofac Implants. 1995 Nov-Dec;10(6):721-8.
The objective of this study was to determine if the biologically active molecules laminin and fibronectin could influence gingival cell attachment to implant surfaces in vitro. Flat squares of the following implant materials were tested: smooth, plasma-sprayed, and hydroxyapatite-coated titanium. The surfaces were coated with equimolar quantities of either laminin, fibronectin, or bovine serum albumin. Fibronectin coating of implant surfaces resulted in two to three times the enhancement of gingival fibroblast binding on all implant surfaces tested (P < .01), with a lesser effect on epithelial cells. Laminin coating resulted in three to four times the enhancement of gingival epithelial cell binding on all implant surfaces tested (P < .01), with a lesser effect on fibroblasts. The two cell types exhibited distinct preferences for the different molecules tested with the surface roughness having some influence.
本研究的目的是确定生物活性分子层粘连蛋白和纤连蛋白是否能在体外影响牙龈细胞与种植体表面的附着。测试了以下种植体材料的扁平方块：光滑的、等离子喷涂的和羟基磷灰石涂层的钛。表面涂有等摩尔量的层粘连蛋白、纤连蛋白或牛血清白蛋白。种植体表面的纤连蛋白涂层使所有测试种植体表面上牙龈成纤维细胞的结合增强了两到三倍（P <.01），对上皮细胞的影响较小。层粘连蛋白涂层使所有测试种植体表面上牙龈上皮细胞的结合增强了三到四倍（P <.01），对成纤维细胞的影响较小。这两种细胞类型对所测试的不同分子表现出明显的偏好，表面粗糙度有一定影响。
