Lev R, Clark R F
Mercy Hospital and Medical Center, San Diego, California, USA.
J Emerg Med. 1995 Sep-Oct;13(5):649-52. doi: 10.1016/0736-4679(95)00071-h.
Imidazole decongestants are present in a variety of over-the-counter medications, including eye drops and nasal sprays. Their primary mechanism of action is vasoconstriction, accomplished by direct stimulation of alpha receptors on blood vessels. Accidental and intentional poisonings involving these substances are increasing, and can cause mental status and respiratory depression, as well as other effects related to alpha receptor stimulation. We present a case of tetrahydrozoline ingestion in an adult who presented with chest pain, bradycardia, mental status depression, miosis, and other signs and symptoms of imidazole compound poisoning. It is important for physicians to be familiar with the adverse effects of these ingestions and to be aware of the potential therapies for management.
咪唑类减充血剂存在于多种非处方药物中，包括眼药水和鼻喷雾剂。它们的主要作用机制是血管收缩，通过直接刺激血管上的α受体来实现。涉及这些物质的意外和故意中毒事件正在增加，可导致精神状态和呼吸抑制，以及与α受体刺激相关的其他影响。我们报告一例成人摄入四氢唑啉的病例，该患者出现胸痛、心动过缓、精神状态抑郁、瞳孔缩小以及咪唑类化合物中毒的其他体征和症状。医生熟悉这些摄入物的不良反应并了解潜在的治疗方法很重要。
