Jensen P, Edgren B, Hall L, Ring J C
College of Pharmacy, University of Minnesota, Minneapolis.
Pediatr Emerg Care. 1989 Jun;5(2):110-2. doi: 10.1097/00006565-198906000-00011.
Toxic ingestions constitute a major health problem for infants and young children, with an estimated 500,000 poisonings in 1980, 90% of them in children less than five years old. Mortality and associated expense are considerable. Sympathetic amines, while less commonly involved in pediatric poisonings, deserve special attention because of their potent cardiovascular side effects, eg, tachycardia and hypertension. Tetrahydrozoline, the active ingredient in several nasal and ophthalmologic over-the-counter medications, has previously been implicated in childhood ingestions. We report a case of tetrahydrozoline ingestion in which, paradoxically, lethargy, bradycardia, and hypotension were noted.
有毒物质摄入是婴幼儿面临的一个主要健康问题，据估计1980年有50万起中毒事件，其中90%发生在五岁以下儿童身上。死亡率和相关费用相当可观。交感胺虽然在儿科中毒事件中较少涉及，但因其强大的心血管副作用，如心动过速和高血压，值得特别关注。四氢唑啉是几种鼻用和眼科非处方药物中的活性成分，此前曾与儿童中毒事件有关。我们报告了一例四氢唑啉摄入病例，奇怪的是，该病例出现了嗜睡、心动过缓和低血压症状。
