Ianelli S, Mazza P, Orcesi M, Pelizzi C, Pelizzi G, Zani F
Dipartimento di Chimica Generale ed Inorganica, Chimica Analitica, Chimica Fisica, Università di Parma, Italy.
J Inorg Biochem. 1995 Nov 1;60(2):89-108. doi: 10.1016/0162-0134(95)00005-9.
The ligand behavior of di-2-pyridylketone 2-aminobenzoylhydrazone (Hdpa), and phenyl(2-pyridyl)ketone 2-aminobenzoylhydrazone (Hdba) towards organotin derivatives was investigated. The synthesis and the IR and 119Sn NMR spectroscopic characterization of the compounds is reported, together with the X-ray crystal structures of Hdpa and Sn(C6H5)3Cl(OH2).Hdpa, which are discussed and compared. The in vitro evaluation of antimicrobial properties revealed the strong activity of Sn(C6H5)2(Hdpa)Cl2 and Sn(C6H5)3Cl(OH2).Hdpa complexes. None of the compounds showed genotoxicity in the Bacillus subtilis rec-assay and in the Salmonella-microsome test.
研究了二 - 2 - 吡啶基甲酮2 - 氨基苯甲酰腙（Hdpa）和苯基（2 - 吡啶基）甲酮2 - 氨基苯甲酰腙（Hdba）对有机锡衍生物的配体行为。报道了这些化合物的合成、红外光谱和119Sn核磁共振光谱表征，以及Hdpa和Sn(C6H5)3Cl(OH2).Hdpa的X射线晶体结构，并对其进行了讨论和比较。抗菌性能的体外评估显示Sn(C6H5)2(Hdpa)Cl2和Sn(C6H5)3Cl(OH2).Hdpa配合物具有很强的活性。在枯草芽孢杆菌重组试验和沙门氏菌 - 微粒体试验中，这些化合物均未显示出遗传毒性。
