含吡咯-2,5-二甲醛双（酰腙）的有机锡配合物。合成、结构、抗菌活性及遗传毒性

Organotin complexes with pyrrole-2,5-dicarboxaldehyde bis(acylhydrazones). Synthesis, structure, antimicrobial activity and genotoxicity.

作者信息

Bacchi A, Bonardi A, Carcelli M, Mazza P, Pelagatti P, Pelizzi C, Pelizzi G, Solinas C, Zani F

机构信息

Dipartimento di Chimica Generale ed Inorganica, Chimica Analitica, Chimica Fisica, Università di Parma, Italy.

出版信息

J Inorg Biochem. 1998 Feb 1;69(1-2):101-12. doi: 10.1016/s0162-0134(97)10027-7.

DOI:10.1016/s0162-0134(97)10027-7

PMID:9606941

Abstract

Mono- and bimetallic organotin complexes with pyrrole-2,5-dicarboxaldehyde bis(2-hydroxybenzoylhydrazone) (H5dfps) and pyrrole-2,5-dicarboxaldehyde bis(2-picolinoylhydrazone) (H3dfpp) were synthesized and characterized by IR, 1H and 119Sn NMR spectroscopy. X-ray analysis of the complex [Sn(H3dfps)(C6H5)2].(CH3)2SO revealed a pentacoordination around tin through a N,N,O terdentate ligand behaviour of the hydrazone. This complex is the most active compound, exhibiting MIC values of 3 and 12 micrograms/ml against Gram positive and Gram negative bacteria, respectively. None of the ligands or complexes produced DNA-damage in the Bacillus subtilis rec-assay or showed mutagenic activity in the Salmonella-microsome test.

摘要

合成了含有吡咯-2,5-二甲醛双（2-羟基苯甲酰腙）（H5dfps）和吡咯-2,5-二甲醛双（2-吡啶甲酰腙）（H3dfpp）的单金属和双金属有机锡配合物，并通过红外光谱、1H 和 119Sn 核磁共振光谱对其进行了表征。配合物[Sn(H3dfps)(C6H5)2].(CH3)2SO 的 X 射线分析表明，通过腙的 N,N,O 三齿配体行为，锡周围存在五配位。该配合物是活性最高的化合物，对革兰氏阳性菌和革兰氏阴性菌的最低抑菌浓度分别为 3 和 12 微克/毫升。在枯草芽孢杆菌重组试验中，没有一种配体或配合物产生 DNA 损伤，在沙门氏菌-微粒体试验中也没有显示出诱变活性。