Terryberry J, Sutjita M, Shoenfeld Y, Gilburd B, Tanne D, Lorber M, Alosachie I, Barka N, Lin H C, Youinou P
Specialty Laboratories, Santa Monica, CA 90404-3900, USA.
J Clin Lab Anal. 1995;9(5):308-19. doi: 10.1002/jcla.1860090506.
We surveyed the frequency of reported infections and target autoantigens in 56 Guillain Barré syndrome (GBS) patients by detecting antibodies to myelin and microbes. Sulfatide (43%), cardiolipin (48%), GD1a (15%), SGPG (11%), and GM3 (11%) antibodies were the most frequently detected heterogenous autoantibodies. A wide spectrum of antimicrobial IgG and IgM antibodies were also detected; mumps-specific IgG (66%), adenovirus-specific IgG (52%), varicella-zoster virus-specific IgG (46%), and S. pneumoniae serotype 7-specific IgG (45%) were the most prevalent. Our results indicate that polyclonal expansion of physiologic and pathologic antibodies and/or molecular mimicry likely occurs following infection and is related to other autoimmune factors in the etiology of GBS. Although no single definitive myelin-specific autoantibody was identified, our results suggest a unique pattern of reactivity against autoantigens.
我们通过检测针对髓磷脂和微生物的抗体，调查了56例吉兰-巴雷综合征（GBS）患者报告感染的频率和靶自身抗原。硫脂（43%）、心磷脂（48%）、GD1a（15%）、SGPG（11%）和GM3（11%）抗体是最常检测到的异源性自身抗体。还检测到了广泛的抗微生物IgG和IgM抗体；腮腺炎特异性IgG（66%）、腺病毒特异性IgG（52%）、水痘-带状疱疹病毒特异性IgG（46%）和肺炎链球菌7型特异性IgG（45%）最为普遍。我们的结果表明，感染后可能发生生理性和病理性抗体的多克隆扩增和/或分子模拟，并且与GBS病因中的其他自身免疫因素有关。虽然未鉴定出单一明确的髓磷脂特异性自身抗体，但我们的结果提示了针对自身抗原的独特反应模式。
