Yuki N, Tagawa Y
Department of Biochemistry, Faculty of Medicine, Tokyo Medical and Dental University, Japan.
J Neurol Sci. 1998 Jan 21;154(1):14-7. doi: 10.1016/s0022-510x(97)00174-3.
Guillain-Barré syndrome (GBS) sometimes is preceded by cytomegalovirus (CMV) infection. Irie et al. (J. Neuroimmunol. 1996;68:19-26) reported that three patients with GBS subsequent to CMV infection had IgM and IgG anti-GM2 antibodies. In our larger study, the IgMs from the CMV-associated GBS patients showed significantly higher anti-GM2 antibody titers than anti-GM3, anti-GD1a, anti-GD1b, anti-GD2, anti-GD3, anti-GT1b, anti-GQ1b, and anti-SGPG antibody titers. None of the anti-glycosphingolipid antibody titers differed significantly from the others in the IgGs from the CMV-associated GBS patients. However, IgM anti-GM2 antibody frequently was present in GBS patients who were not preceded by CMV infection and non-GBS patients with acute CMV infection. Our results did not support the conclusion of Irie et al. that anti-GM2 antibodies were closely associated with acute CMV infection in GBS, but acute CMV infection, with and without GBS, was associated with IgM anti-GM2 antibody.
吉兰-巴雷综合征（GBS）有时在巨细胞病毒（CMV）感染之后出现。Irie等人（《神经免疫学杂志》，1996年；68:19 - 26）报告称，3例CMV感染后发生GBS的患者有IgM和IgG抗GM2抗体。在我们规模更大的研究中，CMV相关GBS患者的IgM显示，其抗GM2抗体滴度显著高于抗GM3、抗GD1a、抗GD1b、抗GD2、抗GD3、抗GT1b、抗GQ1b和抗SGPG抗体滴度。在CMV相关GBS患者的IgG中，抗糖鞘脂抗体滴度彼此之间没有显著差异。然而，在未先发生CMV感染的GBS患者以及急性CMV感染的非GBS患者中，IgM抗GM2抗体也经常出现。我们的结果并不支持Irie等人的结论，即抗GM2抗体与GBS中的急性CMV感染密切相关，而是无论有无GBS，急性CMV感染都与IgM抗GM2抗体有关。
