Bailey D N
Department of Pathology, University of California Medical Center, San Diego 92103-8320, USA.
J Anal Toxicol. 1995 Jul-Aug;19(4):205-8. doi: 10.1093/jat/19.4.205.
The formation of cocaisopropylene (CI), the isopropyl homologue of cocaine (COC), was demonstrated by the incubation of whole human liver homogenates with cocaine hydrochloride and isopropanol. Measurable concentrations of CI were noted within 1 h of incubation. The reaction was completely inhibited by sodium fluoride. As a control on hepatic enzymatic activity, aliquots of the same homogenates were also incubated with COC and ethanol to yield cocaethylene (CE), which was previously demonstrated by this system. Peak concentrations of CI were approximately 0.1-0.2 of those of CE.
通过将人肝匀浆与盐酸可卡因和异丙醇一起孵育，证明了可卡因异丙基同系物——可卡因异丙酯（CI）的形成。孵育1小时内即可检测到CI的浓度。该反应被氟化钠完全抑制。作为肝脏酶活性的对照，相同匀浆的等分试样也与可卡因（COC）和乙醇一起孵育以产生可卡乙烯（CE），该系统先前已证明了可卡乙烯的产生。CI的峰值浓度约为CE的0.1 - 0.2。
