Bailey D N
Department of Pathology, University of California, San Diego Medical Center 92103-8320, USA.
Ther Drug Monit. 1996 Jun;18(3):280-3. doi: 10.1097/00007691-199606000-00010.
The tissue binding of cocaine (COC) and cocaethylene (CE) was investigated by equilibrium dialysis of homogenates of whole human tissue supplemented with either COC or CE at concentrations of 10 and 50 microM for each drug. Concentrations of COC and CE were measured by high-pressure liquid chromatography. Kidney bound COC predominantly whereas serum bound it the least (about one tenth as much). In contrast, for CE, most binding was noted to brain with the least to serum (about one twentieth as much). Heart, placenta, and liver showed intermediate binding overall. The binding of COC and CE to these tissues may be important in understanding specific target-organ activity of both compounds.
通过对添加浓度分别为10微摩尔和50微摩尔的可卡因（COC）或古柯乙烯（CE）的全人体组织匀浆进行平衡透析，研究了COC和CE的组织结合情况。通过高压液相色谱法测量COC和CE的浓度。肾脏对COC的结合占主导，而血清对其结合最少（约为肾脏的十分之一）。相比之下，对于CE，大脑的结合最多，血清的结合最少（约为大脑的二十分之一）。心脏、胎盘和肝脏总体上表现出中等程度的结合。COC和CE与这些组织的结合对于理解这两种化合物的特定靶器官活性可能很重要。
