Williamson J A, Lieder P H, Amegashitsi L
E.I. DuPont DeNemours & Company, Inc., Haskell Laboratory, Newark, DE 19714, USA.
J Anal Toxicol. 1995 Jul-Aug;19(4):256-60. doi: 10.1093/jat/19.4.256.
We describe a method for the measurement of a metabolite of ortho-toluidine in urine. The method uses capillary gas chromatographic separation with mass spectrometric detection to quantitate the metabolite, and it requires no derivatization or extraction of the urine sample prior to analysis. Quantitation is accomplished by comparison with a control spiked with a standard of the metabolite. The coefficient of variation for day-to-day reproducibility of the assay was 9.7%. The limit of quantitation was 10 micrograms/L (10 parts per billion).
我们描述了一种测量尿液中邻甲苯胺代谢物的方法。该方法采用毛细管气相色谱分离结合质谱检测来定量代谢物，分析前无需对尿液样本进行衍生化或提取。通过与添加了代谢物标准品的对照进行比较来完成定量。该检测方法的日间重复性变异系数为9.7%。定量限为10微克/升（十亿分之十）。
