Dominici C, Gregory S, Padula A, Fares C, Ceccamea A, Castello M A
Department of Pediatrics, University La Sapienza, Rome, Italy.
Med Pediatr Oncol. 1996 Feb;26(2):125-8. doi: 10.1002/(SICI)1096-911X(199602)26:2<125::AID-MPO10>3.0.CO;2-H.
The case of a 7-year-old boy presenting at diagnosis with a localized (stage III) Wilms' tumor of favorable histology is presented. Immunocytologic analysis of bone marrow aspirates revealed cells positive for neural cell adhesion molecule (NCAM) and negative for class I major histocompatibility complex (MHC) antigens. These cells were interpreted as deriving from the tumor blastemal component. Postoperatively the child underwent radiotherapy and chemotherapy, and he remains free of disease 12 months after completion of therapy. In patients with nonmetastatic Wilms' tumor at onset, the evaluation of the actual frequency of occult marrow involvement and the assessment of its clinical significance may necessitate further investigation.
本文报告了一名7岁男孩的病例，该男孩在诊断时患有组织学良好的局限性（III期）肾母细胞瘤。骨髓穿刺液的免疫细胞分析显示，神经细胞黏附分子（NCAM）呈阳性、I类主要组织相容性复合体（MHC）抗原呈阴性的细胞。这些细胞被认为来源于肿瘤的原始成分。术后该患儿接受了放疗和化疗，在治疗完成12个月后仍无疾病迹象。对于初发时无转移的肾母细胞瘤患者，评估隐匿性骨髓受累的实际发生率及其临床意义可能需要进一步研究。
