Fichera G, Rossi G
Cattedra di Istitituzioni di Anatomia e Istologia Patologia, Università di Catania.
Pathologica. 1995 Apr;87(2):148-53.
Laryngeal chondrosarcoma is an uncommon mesenchymal tumor and in the world literature only 220 cases have been reported. We report in this retrospective examination three cases which age ranged from 54 to 65 years; one was a man and two were women. Two of the tumors arose in the thyroid cartilage, one in the cricoid cartilage. All the cases corresponded to low-grade, well-differentiated chondrosarcomas of the hyaline type (grade I) and two of the patients were alive and free from recurrence or metastasis after 6 and 12 years. One had a recurrence 5 years later with a superior histologic grade (grade II) and died 6 months after laryngectomy from metastatic disease. The AA. discusses the importance of assessing location, size, state of the resection borders, histologic grade and recurrence for the correct evaluation of the neoplasia, for therapeutic and prognostic purposes.
喉软骨肉瘤是一种罕见的间叶组织肿瘤，在世界文献中仅报道过220例。在本次回顾性研究中，我们报告了3例患者，年龄在54至65岁之间；1例为男性，2例为女性。其中2例肿瘤发生于甲状软骨，1例发生于环状软骨。所有病例均为低度、高分化的透明型软骨肉瘤（I级），2例患者分别在6年和12年后存活且无复发或转移。1例患者在5年后复发，组织学分级较高（II级），并在喉切除术后6个月因转移性疾病死亡。本文作者讨论了评估肿瘤位置、大小、切除边缘状态、组织学分级和复发情况对于肿瘤正确评估、治疗及预后判断的重要性。
