高密度脂蛋白胆固醇的增加与体外甘油三酯的降解有关。

HDL-cholesterol increase associated to triglycerides degradation in vitro.

作者信息

Jimeno B, Zubeldia M A, Gómez M G, Campillo J E, Mena P

机构信息

Departamento de Fisiologia, Facultad de Medicina, Universidad de Extremadura, Badajoz, Spain.

出版信息

Rev Esp Fisiol. 1995 Jun;51(2):101-4.

PMID:8532949

Abstract

The effect of muscle tissue from rats trained by swimming on the extracellular degradation of triglyceride (TG) rich particles has been studied in vitro. During incubation, there is a progressive decline of the TG concentration in the incubation medium. At the end of the incubation period (90 min), a significantly reduction in the TG levels (p < 0.05) is associated with a significant increase in the high-density lipoprotein (HDL) cholesterol level (p < 0.005). There are no significant changes in total cholesterol levels. The correlation of the TG decline with the HDL-cholesterol increase is significant (r = 0.695, p < 0.05, n = 25). The experimental model used here could be of great interest for the in vitro study of factors affecting lipid levels in plasma.

摘要

体外研究了游泳训练大鼠的肌肉组织对富含甘油三酯（TG）颗粒细胞外降解的影响。在孵育过程中，孵育培养基中TG浓度逐渐下降。孵育期结束时（90分钟），TG水平显著降低（p < 0.05），同时高密度脂蛋白（HDL）胆固醇水平显著升高（p < 0.005）。总胆固醇水平无显著变化。TG下降与HDL胆固醇升高之间的相关性显著（r = 0.695，p < 0.05，n = 25）。这里使用的实验模型对于体外研究影响血浆脂质水平的因素可能具有很大的意义。