碱基切除修复途径。
The base excision repair pathway.
作者信息
Seeberg E, Eide L, Bjørås M
机构信息
Ecole Supérieure de Biotechnologie de Strasbourg, UPR9003 de CNRS, Unité de Cancérogenèse et de Mutagenèse Moléculaire et Structurale, Illkirch-Graffenstaden, France.
出版信息
Trends Biochem Sci. 1995 Oct;20(10):391-7. doi: 10.1016/s0968-0004(00)89086-6.
The base excision repair pathway has evolved to protect cells from the deleterious effects of endogenous DNA damage induced by hydrolysis, reactive oxygen species and other intracellular metabolites that modify DNA base structure. However, base excision repair is also important to resist lesions produced by ionizing radiation and strong alkylating agents, which are similar to those induced by endogenous factors.
碱基切除修复途径的进化是为了保护细胞免受由水解、活性氧和其他改变DNA碱基结构的细胞内代谢物诱导的内源性DNA损伤的有害影响。然而，碱基切除修复对于抵抗电离辐射和强烷基化剂产生的损伤也很重要，这些损伤与内源性因素诱导的损伤相似。
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