Brownlie J, Clarke M C, Hooper L B, Bell G D
Institute for Animal Health, Compton, Newbury, Berkshire.
Vet Rec. 1995 Jul 15;137(3):58-62. doi: 10.1136/vr.137.3.58.
A model is described for the validation of vaccines designed to protect the bovine fetus from bovine viral diarrhoea virus (BVDV). The fetopathic nature of the challenge strain of virus was confirmed and the method used to test a commercial vaccine (Bovidec) developed from a Compton prototype. Heifers were vaccinated two or three times about the time of impregnation and challenged when they were between 25 and 80 days of gestation. There was no evidence of a viraemia in the heifers after the challenge, or of infection with BVDV of 13 liveborn calves or two aborted fetuses.
描述了一种用于验证旨在保护牛胎儿免受牛病毒性腹泻病毒（BVDV）感染的疫苗的模型。确认了病毒攻击株的致病特性，并采用该方法测试了一种基于康普顿原型开发的商业疫苗（Bovidec）。在受孕前后，对小母牛进行了两到三次疫苗接种，并在妊娠25至80天时对其进行攻击。攻击后，小母牛没有出现病毒血症的迹象，13头活产犊牛和2头流产胎儿也没有感染BVDV。
