Chan J C, Oldham S B, DeLuca H F
J Pediatr. 1977 May;90(5):820-4. doi: 10.1016/s0022-3476(77)81261-4.
Two children who were receiving maintenance hemodialysis were treated with 1 to 4 microng/day of 1 alpha-hydroxyvitamin D3 for 500 to 700 days, respectively. Sequential parathyroid hormone levels and radiologic evaluations showed considerable improvement in one patient. The second patient initially responded with healing of the bone disease. Subsequent deterioration may be related either to medical noncomplicance and/or interference by diphenylhydantoin in the subsequent hepatic 25-hydroxylation of 1 alpha-OH-D3.
两名正在接受维持性血液透析的儿童分别接受了每天1至4微克的1α-羟基维生素D3治疗，治疗时间分别为500至700天。连续的甲状旁腺激素水平和放射学评估显示，其中一名患者有显著改善。第二名患者最初出现骨病愈合。随后的病情恶化可能与医疗不依从和/或苯妥英对随后1α-OH-D3的肝脏25-羟化的干扰有关。
