Günter H H, Woschko M, Messner U, Niesert S
Zentrum Frauenheilkunde, Medizinischen Hochschule Hannover.
Zentralbl Gynakol. 1995;117(11):592-7.
The concentrations of the atrial natriuretic peptide (ANP) during the 3rd trimester of pregnancy (n = 54), the 1st, 2nd, and 3rd day post partum and in 10 non pregnant females were measured and compared. Moreover ANP was determined in the umbilical cord (artery n = 10, vein n = 48) and the influence of exercise on the concentration of ANP in pregnant (n = 10) and non pregnant women (n = 10) was analyzed. There was no significant difference of the ANP-values measured in non pregnant patients and during the third trimester (100 +/- 57 vs. 97 +/- 27 pg/ml). On the 3rd day post partum a significant rise of ANP was noted (1st day post partum 78 +/- 43, 3rd day post partum 102 +/- 46, 5th day post partum 84 +/- 40 pg/ml). During physical exercise the concentration of ANP increases significantly in pregnant (103 +/- 45 vs. 120 +/- 57 pg/ml, p < 0.05) as well as in non pregnant females (97 +/- 27 vs. 111 +/- 39 pg/ml, p < 0.05). In arterial blood samples from the umbilical cord the concentration of ANP was higher than in venous cord blood (62 +/- 34 vs. 51 +/- 28 pg/ml, p > 0.05).
对54例妊娠晚期孕妇、产后第1、2、3天的产妇以及10例非妊娠女性的心房利钠肽（ANP）浓度进行了测量和比较。此外，还测定了脐带血中的ANP（动脉血n = 10，静脉血n = 48），并分析了运动对妊娠女性（n = 10）和非妊娠女性（n = 10）ANP浓度的影响。非妊娠患者和妊娠晚期测量的ANP值无显著差异（100±57 vs. 97±27 pg/ml）。产后第3天ANP显著升高（产后第1天78±43，产后第3天102±46，产后第5天84±40 pg/ml）。在体育锻炼期间，妊娠女性（103±45 vs. 120±57 pg/ml，p < 0.05）和非妊娠女性（97±27 vs. 111±39 pg/ml，p < 0.05）的ANP浓度均显著增加。脐带动脉血样本中的ANP浓度高于脐静脉血（62±34 vs. 51±28 pg/ml，p > 0.05）。
