Hara T, Matsuo M, Tasaki R, Miyazaki S, Bamba M
Division of Child Neurology, Tottori University School of Medicine, Japan.
Acta Paediatr Jpn. 1995 Oct;37(5):575-8. doi: 10.1111/j.1442-200x.1995.tb03379.x.
We evaluated the clinical significance of measurement of urinary neopterin levels in primary immunodeficiencies and persistent infections exclusively at afebrile or asymptomatic periods. Despite the examinations at afebrile or asymptomatic periods, urinary neopterin levels were elevated in some patients with primary immunodeficiencies and in patients with persistent infections of human immunodeficiency virus (HIV) or Epstein-Barr virus (EBV). Therefore, urinary neopterin measurement at afebrile periods will be useful as one of the screening tests in the detection of such disorders among children with occasional episodes of infections.
我们专门在无发热或无症状期评估了原发性免疫缺陷和持续性感染患者尿新蝶呤水平测定的临床意义。尽管是在无发热或无症状期进行检测，但部分原发性免疫缺陷患者以及感染人类免疫缺陷病毒（HIV）或爱泼斯坦-巴尔病毒（EBV）的持续性感染患者的尿新蝶呤水平仍升高。因此，在无发热期测定尿新蝶呤将有助于作为一种筛查试验，用于在偶发感染的儿童中检测此类疾病。
