Sergeev A N, Lub M Iu, P'iankova O G, Kotliarov L A
Antibiot Khimioter. 1995 May;40(5):24-7.
The study of the preventive and therapeutic action of some immunomodulators (ridostin, reaferon and polyribonate) used alone and in combinations was conducted on laboratory animals infected aerogenically by Marburg or Ebola virus. It was found that special preventive intranasal and intramuscular administration of ridostin provided protection of the animals infected by Marburg virus (p = 0.1) and an increase in their mean lifespan by 2.4 days (p = 0.15). In the Ebola infection combined administration of ridostin and reaferon caused an essential increase in the mean lifespan of the animals by 2.9 days (p = 0.04). None of the tested drugs had any significant positive effect when used in various combinations according to the treatment schemes in Marburg and Ebola infections in guinea pigs.
对单独使用及联合使用某些免疫调节剂（利多司汀、重组干扰素和聚肌胞苷酸）的预防和治疗作用进行了研究，实验对象为经空气感染马尔堡或埃博拉病毒的实验动物。结果发现，利多司汀经特殊的预防性鼻内和肌肉注射给药，可保护感染马尔堡病毒的动物（p = 0.1），并使其平均寿命延长2.4天（p = 0.15）。在埃博拉感染中，利多司汀和重组干扰素联合给药可使动物平均寿命显著延长2.9天（p = 0.04）。在豚鼠的马尔堡和埃博拉感染中，根据治疗方案将所测试的药物以各种组合使用时，均未产生任何显著的积极效果。
