Sergeev A N, Ryzhikov A B, Bulychev L E, Evtin N K, P'iankov O V, P'iankova O G, Slezkina E I, Kotliarov L A, Petrishchenko V A, Pliasunov I V
Vopr Virusol. 1997 Sep-Oct;42(5):226-9.
Therapeutic and prophylactic effects of immunomodifiers ridostin, reaferon, and polyribonate used alone and in various combinations were assessed in experiments on guinea pigs infected with Venezuelan equine encephalomyelitis (VEE) (strain Trinidad), Marburg (strain Popp), and Ebola (M/C-8 variant of Zaire strain) viruses at doses 5 to 20 respiratory LD50 through the respiratory airways. Urgent prophylactic simultaneous intramuscular and intranasal administration of ridostin protected the animals infected with Marburg virus (p = 0.1) and prolonged their life span by 2.4 days (p = 0.15). In Ebola infection a combination of ridostin and reaferon appreciably prolonged the mean life span: by 2.9 days (p = 0.04). In VEE ridostin alone or in combination with reaferone appreciably increased the share of survivors; ridostin with reaferon and polyribonate notably prolonged the mean life span of infected animals. None of these drugs or combinations produced an appreciable therapeutic effect in any of the studied infections.
在感染委内瑞拉马脑炎（VEE）（特立尼达毒株）、马尔堡（波普毒株）和埃博拉（扎伊尔毒株的M/C - 8变种）病毒的豚鼠实验中，评估了单独使用以及以各种组合使用免疫调节剂利度司亭、干扰素和聚肌胞苷酸的治疗和预防效果，通过呼吸道以5至20个呼吸道半数致死剂量给药。对感染马尔堡病毒的动物进行紧急预防性同时肌内和鼻内注射利度司亭，可起到保护作用（p = 0.1），并将其寿命延长2.4天（p = 0.15）。在埃博拉感染中，利度司亭和干扰素的组合明显延长了平均寿命：延长了2.9天（p = 0.04）。在VEE感染中，单独使用利度司亭或与干扰素联合使用可显著提高存活者比例；利度司亭与干扰素和聚肌胞苷酸显著延长了感染动物的平均寿命。在任何一种所研究的感染中，这些药物或组合均未产生明显的治疗效果。
