抗有机磷神经毒剂维埃克斯单克隆抗体的制备、特性鉴定及应用
Production, characterization and application of monoclonal antibodies against the organophosphorus nerve agent Vx.
作者信息
Ci Y X, Zhou Y X, Guo Z Q, Rong K T, Chang W B
机构信息
Department of Chemistry, Peking University, Beijing, China.
出版信息
Arch Toxicol. 1995;69(8):565-7. doi: 10.1007/s002040050213.
Two monoclonal antibodies (Vx-BB8 and Vx-EA11) to the chemical warfare agent Vx were produced and characterized. A competitive inhibition enzyme immunoassay was developed to detect Vx concentrations as low as 3.7 x 10(-7) - 3.7 x 10(-6) mol/l in biological samples. Vx-BB8 400 micrograms given intravenously immediately before 1 x LD95 Vx or 400 micrograms Vx-BB8 intraperitoneally 1.5 h-3 days before 1 x LD95 Vx could protect all the tested mice from death.
制备并表征了两种针对化学战剂VX的单克隆抗体（Vx-BB8和Vx-EA11）。开发了一种竞争性抑制酶免疫测定法，用于检测生物样品中低至3.7×10⁻⁷ - 3.7×10⁻⁶ mol/l的VX浓度。在1×LD95 VX之前立即静脉注射400微克Vx-BB8，或在1×LD95 VX之前1.5小时至3天腹腔注射4００微克Vx-BB8，可以保护所有受试小鼠免于死亡。
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