Nunes M L, da Costa J C, da Silva L F
Division of Neurology, São Lucas Hospital, Porto Alegre, Brazil.
Pediatr Neurol. 1995 Sep;13(2):153-6. doi: 10.1016/0887-8994(95)00145-6.
Six cases of subacute sclerosing panencephalitis (1 stage I, 3 stage II, 2 stage III) were diagnosed at our institution in the last 10 years. Five patients were treated with isoprinosine and the antiepileptic drug valproic acid. Three patients presented with myoclonic seizures refractory to valproic acid and the usual antiepileptic therapy. They received trihexyphenidyl with good results. We suggest the use of trihexyphenidyl in combination with isoprinosine in patients with subacute sclerosing panencephalitis with myoclonic seizures refractory to valproic acid.
