Krogerus L A, Railo M, Schoultz M, Nordling S
Department of Pathology, University of Helsinki, Finland.
Anal Quant Cytol Histol. 1995 Oct;17(5):309-13.
One of the prognostic factors in breast cancer is the proliferation activity of the tumor. This study sought knowledge of this activity before surgery to benefit the design and timing of therapy.
Flow cytometric DNA analysis data from 52 diagnostic fine needle aspirates were compared with data from subsequent surgical specimens.
The data showed that the coefficient of variation of the G1 peak was lower in the aspirates. Small, near-diploid peaks were detected more frequently in aspirate histograms than in surgical specimens. DNA analyses by flow cytometry from aspirates, which can be obtained prior to surgical treatment, were as reliable as those obtained from surgical specimens, provided that the cellular material was diagnostic of cancer.
Our results suggest that flow cytometry DNA analysis from the first preoperative cytologic specimen from a breast tumor will permit faster planning and coordination of breast cancer care.
乳腺癌的预后因素之一是肿瘤的增殖活性。本研究旨在术前了解该活性，以利于治疗方案的设计和时机安排。
将52份诊断性细针穿刺抽吸物的流式细胞术DNA分析数据与后续手术标本的数据进行比较。
数据显示，抽吸物中G1峰的变异系数较低。在抽吸物直方图中比手术标本中更频繁地检测到小的、近二倍体峰。只要细胞材料能诊断为癌症，术前手术治疗前获得的抽吸物的流式细胞术DNA分析与手术标本获得的分析一样可靠。
我们的结果表明，对乳腺肿瘤术前第一份细胞学标本进行流式细胞术DNA分析将有助于更快地规划和协调乳腺癌治疗。
