来自腺毛香茶菜的细胞毒性对映-贝壳杉烯二萜类化合物。

Cytotoxic ent-kaurene diterpenoids from Isodon gesneroides.

作者信息

Sun H D, Lin Z W, Niu F D, Zhen Q T, Wu B, Lin L Z, Cordell G A

机构信息

Laboratory of Phytochemistry, Kunming Institute of Botany, Academia Sinica, Yunnan, P.R. China.

出版信息

Phytochemistry. 1995 Nov;40(5):1461-7. doi: 10.1016/0031-9422(95)00373-f.

DOI:10.1016/0031-9422(95)00373-f

PMID:8534404

Abstract

From Isodon gesneroides, three new cytotoxic diterpenoids, gesneroidins A, B and C, together with one known diterpenoid, dawoensin A, were isolated, and the structure determination and unambiguous assignment of their stereochemistry and NMR spectral data were made by a combination of one-and two-dimensional NMR techniques, computer modelling calculations and X-ray analysis.

摘要

从腺毛香茶菜中分离得到了三种新的具有细胞毒性的二萜类化合物，即腺毛香茶素A、B和C，以及一种已知的二萜类化合物大叶香茶菜甲素，并通过一维和二维核磁共振技术、计算机模拟计算和X射线分析相结合的方法对其结构进行了确定，明确了它们的立体化学和核磁共振光谱数据。