三种香茶菜属植物中的细胞毒性对映-贝壳杉烯二萜类化合物。

Cytotoxic ent-kaurene diterpenoids from three Isodon species.

作者信息

Sun H D, Lin Z W, Niu F D, Lin L Z, Chai H B, Pezzuto J M, Cordell G A

机构信息

Laboratory of Phytochemistry, Kunming Institute of Botany, Academia Sinica, Yunnan Province, P.R. China.

出版信息

Phytochemistry. 1995 Jan;38(2):437-42. doi: 10.1016/0031-9422(94)00626-5.

DOI:10.1016/0031-9422(94)00626-5

PMID:7539618

Abstract

From Isodon loxothyrsa, one new diterpenoid, loxothyrin A, together with one known diterpenoid, adenolin B, from I.pleiophyllus, three known diterpenoids, coetsoidins A, B and G, and from I. adenoloma, one known diterpenoid, longikaurin F, were isolated. The structure determination of loxothyrin A, and the unambiguous NMR spectral assignments of the known compounds were made by a combination of 1D and 2D NMR techniques and computer modelling calculations. The isolates showed potent cytotoxic activities.

摘要

从线齿香茶菜中分离得到一个新的二萜类化合物——线齿香茶菜素A，从多叶香茶菜中得到一个已知的二萜类化合物——腺叶香茶菜素B，从台湾香茶菜中得到三个已知的二萜类化合物——台湾香茶菜素A、B和G，从腺毛香茶菜中得到一个已知的二萜类化合物——长叶贝壳杉苷F。通过一维和二维核磁共振技术以及计算机模拟计算相结合的方法确定了线齿香茶菜素A的结构，并对已知化合物进行了明确的核磁共振光谱归属。这些分离得到的化合物显示出较强的细胞毒活性。