来自蜜香香茶菜的二萜类化合物。

Diterpenoids from Isodon melissoides.

作者信息

Zhao Ai-Hua, Han Quan-Bin, Li Rong-Tao, Li Sheng-Hong, Qing Chen, Zhang Yan-Li, Zhao Qin-Shi, Wang Fu-Sheng, Sun Han-Dong

机构信息

State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, People's Republic of China.

出版信息

J Nat Prod. 2004 Sep;67(9):1441-4. doi: 10.1021/np030418l.

DOI:10.1021/np030418l

PMID:15387638

Abstract

Nine new diterpenoids, melissoidesins M-U (1-9), along with five known analogues, melissoidesin F (10), xindongnin B (11), melissoidesin G (12), melissoidesin E (13), and dawoensin A (14), were isolated from the aerial parts of Isodon melissoides. The structures of new compounds were elucidated by analysis of spectral evidence including extensive 2D NMR data. Compounds 2, 3, 7, 11, 12, and 14 showed cytotoxicity against the human tumor BGC-823 cell line with IC(50) values less than 10 microg/mL, respectively.

摘要

从线纹香茶菜地上部分分离得到9个新的二萜类化合物，香茶菜素M-U（1-9），以及5个已知类似物，香茶菜素F（10）、新冬宁B（11）、香茶菜素G（12）、香茶菜素E（13）和大窝ensin A（14）。通过包括大量二维核磁共振数据在内的光谱证据分析阐明了新化合物的结构。化合物2、3、7、11、12和14对人肿瘤BGC-823细胞系显示出细胞毒性，其半数抑制浓度（IC50）值分别小于10微克/毫升。