Hirst L W, Stallard K, Whitby M, Perrin R
Department of Surgery, Princess Alexandra Hospital, Woolloongabba, Qld.
Aust N Z J Ophthalmol. 1995 Aug;23(3):223-5. doi: 10.1111/j.1442-9071.1995.tb00162.x.
A corneal fungal ulcer which appeared to be quite superficial clinically, was found by histologic examination to unexpectedly involve the full thickness of the cornea.
A patient with an apparent superficial corneal fungal ulcer due to Phialophora species was resistant to topical and intravenous antifungal therapy.
Penetrating keratoplasty cured the condition with retention of normal vision with a follow-up of two years.
If keratomycosis is unresponsive to topical and intravenous antifungal therapy, penetrating keratoplasty may be required to eliminate the infection. Resistance to medical therapy might suggest presence of fungus far deeper in the cornea than suspected clinically.
一例临床上看似相当表浅的角膜真菌性溃疡，经组织学检查意外发现已累及角膜全层。
一名因瓶霉属菌种引起明显表浅角膜真菌性溃疡的患者，对局部和静脉抗真菌治疗均耐药。
穿透性角膜移植术治愈了该疾病，随访两年视力保持正常。
如果角膜真菌病对局部和静脉抗真菌治疗无反应，可能需要进行穿透性角膜移植术以消除感染。药物治疗耐药可能提示角膜内真菌存在的深度远比临床怀疑的要深。
