Grzegorzewska A, Mariak I
Department of Nephrology, K. Marcinkowski Academy of Medicine, Poznań, Poland.
Pol J Pharmacol. 1996 Jan-Feb;48(1):99-103.
Our earlier studies indicate that effective peritoneal blood flow (EPBF) during intermittent peritoneal dialysis (IPD) does not depend on gender, age, body mass, renal disease leading to uremia and duration of IPD. Thus, a cause of differences in EPBF observed in uremic patients during IPD is still not clear. The aim of present studies is an evaluation of relationship between arterial blood pressure and EPBF calculated as diffusive mass transfer coefficient of CO2. Studies were performed in 20 patients in the age of 47 +/- 14 (x +/- SD) years, treated with IPD during 4.3 +/- 3.6 months. EPBF and arterial blood pressure were evaluated in the middle of dialysis. Mean arterial pressure was calculated from systolic and diastolic pressure. In patients (n = 10) with greater EPBF (291 +/- 99 ml/min) systolic, diastolic and mean pressures were respectively 166 +/- 24, 100 +/- 20 and 122 +/- 20 mmHg. In patients (n = 10) with smaller EPBF (154 +/- 27 ml/min) respective pressure were 160 +/- 12, 91 +/- 9 and 114 +/- 8 mmHg. The highest but insignificant correlation was found between EPBF and diastolic blood pressure (r = 0.310, n = 20). Patients with significantly higher diastolic (108 +/- 16 mmHg, n = 9, v. 85 +/- 6 mmHg, n = 11) and mean blood pressure (129 +/- 17 v. 108 +/- 2 mmHg) showed insignificantly greater EPBF (260 +/- 121 v. 192 +/- 63 ml/min). Our studies indicate that EPBF during IPD cannot significantly depend on blood pressure.
我们早期的研究表明，间歇性腹膜透析（IPD）期间的有效腹膜血流量（EPBF）并不取决于性别、年龄、体重、导致尿毒症的肾脏疾病以及IPD的持续时间。因此，IPD期间尿毒症患者中观察到的EPBF差异的原因仍不清楚。本研究的目的是评估动脉血压与以二氧化碳扩散质量传递系数计算的EPBF之间的关系。研究在20名年龄为47±14（x±SD）岁的患者中进行，这些患者接受IPD治疗4.3±3.6个月。在透析中期评估EPBF和动脉血压。平均动脉压由收缩压和舒张压计算得出。在EPBF较高（291±99 ml/min）的患者（n = 10）中，收缩压、舒张压和平均压分别为166±24、100±20和122±20 mmHg。在EPBF较低（154±27 ml/min）的患者（n = 10）中，相应的血压分别为160±12、91±9和114±8 mmHg。在EPBF与舒张压之间发现了最高但不显著的相关性（r = 0.310，n = 20）。舒张压（108±16 mmHg，n = 9，对比85±6 mmHg，n = 11）和平均血压显著较高的患者（129±17对比108±2 mmHg）的EPBF略高（260±121对比192±63 ml/min），但差异不显著。我们的研究表明，IPD期间的EPBF不太可能显著依赖于血压。
