Grzegorzewska A E, Mariak I
Department of Nephrology, Karol Marcinkowski, University of Medical Sciences, Poznan, Poland.
Adv Perit Dial. 1996;12:19-23.
The aim of the studies was an evaluation of the correlation between effective peritoneal blood flow (EPBF), blood pressure, and peritoneal transfer during intermittent peritoneal dialysis (IPD). In 20 IPD patients it was shown that EPBF does not depend on either systolic or diastolic blood pressure. Differences in EPBF did not influence peritoneal transfer of small solutes and total protein during the first 25 minutes of dwell, but EPBF dependence of transfer was shown in the later periods of the dwell. Peritoneal transfer rates were greater with higher systolic blood pressure; the significant changes were shown at the beginning (for bicarbonate and total carbon dioxide), in the middle (for urea), and at the end (for uric acid) of the dwell time. Differences in diastolic pressure influenced peritoneal transfer predominantly during the first 25 minutes of dwell, although significant changes during the entire dwell were also observed. Our results indicate that the influence of both EPBF and blood pressure on transport kinetics depends on dwell time: in the first minutes of dwell diastolic blood pressure can predominantly contribute to transfer rates, in later periods the greater role of EPBF in the determination of transfer rates cannot be excluded.
这些研究的目的是评估间歇性腹膜透析（IPD）期间有效腹膜血流量（EPBF）、血压与腹膜转运之间的相关性。在20例IPD患者中发现，EPBF既不依赖于收缩压也不依赖于舒张压。在留腹的前25分钟内，EPBF的差异不影响小分子溶质和总蛋白的腹膜转运，但在留腹后期显示出转运对EPBF的依赖性。收缩压越高，腹膜转运速率越大；在留腹时间开始时（对于碳酸氢盐和总二氧化碳）、中间（对于尿素）和结束时（对于尿酸）显示出显著变化。舒张压的差异主要在留腹的前25分钟影响腹膜转运，不过在整个留腹期间也观察到了显著变化。我们的结果表明，EPBF和血压对转运动力学的影响取决于留腹时间：在留腹的最初几分钟，舒张压可主要影响转运速率，在后期，不能排除EPBF在决定转运速率方面发挥更大作用。
