Brincker H, D'Amore F
Department of Hematology, Odense University Hosptial, Denmark.
Leuk Lymphoma. 1995 Jul;18(3-4):281-8. doi: 10.3109/10428199509059619.
197 cases of gastric lymphoma were reported to a population-based Danish registry of non-Hodgkin's lymphomas. 106 of these cases were localized, representing stages IE and II1E, and were analyzed retrospectively, using Cox regression analysis. 67 had surgical resection, 51 chemotherapy, and 55 radiotherapy, or combinations thereof. No type of treatment showed any superiority as regards survival (p = 0.13). Overall 5-year survival was 67%. The pretherapeutic presence of fever or S-LDH-elevation had a far more significant influence on survival than histology or any of the treatments or treatment combinations. Surgical resection was associated with a significantly higher risk of late complications than radiotherapy, suggesting that radiotherapy may be preferable to surgery as the primary treatment in localized gastric lymphoma. It could not be determined from the available data whether the addition of chemotherapy to the primary treatment provides any survival benefit.
197例胃淋巴瘤病例被报告至丹麦一个基于人群的非霍奇金淋巴瘤登记处。其中106例为局限性病变，代表IE期和II1E期，采用Cox回归分析进行回顾性分析。67例接受了手术切除，51例接受了化疗，55例接受了放疗，或采用了这些治疗方法的联合应用。就生存率而言，没有哪种治疗方法显示出任何优势（p = 0.13）。总体5年生存率为67%。治疗前发热或血清乳酸脱氢酶（S-LDH）升高的存在对生存率的影响远比组织学或任何治疗方法或治疗组合更为显著。与放疗相比，手术切除与更高的晚期并发症风险相关，这表明在局限性胃淋巴瘤的初始治疗中，放疗可能比手术更可取。根据现有数据无法确定在初始治疗中添加化疗是否能带来任何生存益处。
