Cull G M, Howe D J, Stack-Dunne M, Phillips M J, Johnson S A
Department of Haematological Medicine, Taunton and Somerset Hospital, UK.
Leuk Lymphoma. 1995 Oct;19(3-4):355-8. doi: 10.3109/10428199509107910.
We report a case of acute myeloid leukaemia (AML), FAB classification M2, associated with tetrasomy 8. This chromosomal aberration was detected using conventional cytogenetics and flourescent in-situ hybridization (FISH). Using FISH, the pre-treatment cells with tetrasomy 8 were disomic for chromosome 7. A small number of tetrasomy 8 cells were found post-treatment, but these were tetrasomic for chromosome 7. The significance of this is considered, and the literature regarding tetrasomy 8 in acute myeloid leukaemia is reviewed.
我们报告一例急性髓系白血病（AML），FAB分类为M2，伴有8号染色体四体。使用传统细胞遗传学和荧光原位杂交（FISH）检测到这种染色体畸变。使用FISH技术，发现预处理时带有8号染色体四体的细胞7号染色体为二体。治疗后发现少量8号染色体四体细胞，但这些细胞7号染色体为四体。我们探讨了这一现象的意义，并回顾了有关急性髓系白血病中8号染色体四体的文献。
