Vicari L, Sebastio L, Cirigliano V, Pugliese M T, Ferrara F
Medical Genetics Service, Cardarelli Hospital, Naples, Italy.
Leuk Lymphoma. 1995 Oct;19(3-4):351-3. doi: 10.3109/10428199509107909.
We report a case of double isochromosome 8q as a single cytogenetic abnormality in a patient with acute myelo-monocytic leukemia. Similarly to rare cases with tetrasomy 8, the patient showed monocytic involvement and was refractory to cytotoxic chemotherapy. We conclude that this kind of cytogenetic aberration is probably associated with distinct morphologic and clinical characteristics.
