供体淋巴细胞输注用于一名异基因骨髓移植后复发的骨髓增生异常综合征患者。
Donor buffy coat infusions for a patient with myelodysplastic syndrome who relapsed following allogeneic bone marrow transplantation.
作者信息
Tsuzuki M, Maruyama F, Kojima H, Ezaki K, Hirano M
机构信息
Department of Medicine, Fujita Health University, School of Medicine, Aichi, Japan.
出版信息
Bone Marrow Transplant. 1995 Sep;16(3):487-9.
A 49-year-old man with myelodysplastic syndrome (MDS, RAEB in T) who relapsed following allogeneic bone marrow transplantation (allo BMT) was treated with infusions of donor buffy coat leukocytes. He sustained hematologic and cytogenetic remission, but severe graft-versus-host disease (GVHD) developed for which cyclosporin A and prednisolone were required. This therapeutic approach appears to be valuable for relapsed MDS following allo BMT as well as for chronic myelogenous leukemia (CML).
一名49岁的骨髓增生异常综合征（MDS，转化中的难治性贫血伴原始细胞过多，RAEB in T）患者在异基因骨髓移植（allo BMT）后复发，接受了供体富含白细胞层白细胞输注治疗。他实现了血液学和细胞遗传学缓解，但出现了严重的移植物抗宿主病（GVHD），为此需要使用环孢素A和泼尼松龙。这种治疗方法对于allo BMT后复发的MDS以及慢性粒细胞白血病（CML）似乎都有价值。
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