Negru T, Serban M G, Niţă V
C. Davilla University of Medicine and Pharmacy, Department of Physiopathology, Bucharest, Romania.
Rom J Intern Med. 1995 Jan-Jun;33(1-2):55-60.
Changes of the redox balance are reflected at the blood level in old agers--chronically intoxicated with alcohol--presenting degenerative psycho-organic syndromes (DPOS). The parameters investigated were lipid peroxidation reduced glutathione and the total SH groups. The changes of the antioxidant enzymatic system expressed by the activity of superoxide dysmutase, of glutathione peroxidase and of catalase were also followed up. It was observed that compared with the control group the lipid peroxides increased by 70.69% and the blood concentration of G-SH and of the total SH groups decreased by 46.7% and 24.76%, respectively. Likewise enzymes such as GPx and CAT presented increases of 70.4% and respectively 68.3% associated with a decrease of 23.9% of SOD activity.
氧化还原平衡的变化在患有退行性精神-器质性综合征（DPOS）的老年慢性酒精中毒者的血液水平中有所体现。所研究的参数包括脂质过氧化、还原型谷胱甘肽和总巯基。还追踪了由超氧化物歧化酶、谷胱甘肽过氧化物酶和过氧化氢酶活性所表示的抗氧化酶系统的变化。据观察，与对照组相比，脂质过氧化物增加了70.69%，谷胱甘肽（G-SH）和总巯基的血液浓度分别下降了46.7%和24.76%。同样，诸如谷胱甘肽过氧化物酶（GPx）和过氧化氢酶（CAT）等酶分别增加了70.4%和68.3%，同时超氧化物歧化酶（SOD）活性下降了23.9%。
