Serban V, Dabelea D, Deutsch G, Pataki C, Dan I
Department of Diabetes, University for Medicine and Pharmacy, Timişoara, Romania.
Rom J Intern Med. 1995 Jan-Jun;33(1-2):77-83.
It has been suggested that insulin-dependent diabetes mellitus (IDDM) patients have higher values of lipoprotein (a)-Lp (a) that may account for their increased atherogenic risk, as related to non-diabetic subjects. We compared the plasma values of apolipoprotein (a)-(apo) (a) in type 1 diabetic patients (n = 26) hospitalized in our department and in non-diabetic subjects (n = 20) from Timişoara, Romania. IDDM patients had higher levels of apo (a) than controls [115(102-227) vs 58 (51-106) U/l; medians with 95% confidence intervals]; (p = 0.0083). Diabetes duration, the levels of hemoglobin A1 (Hb A1) and the values of body mass index (BMI) were not significantly related to apo(a) concentrations, while no correlations were found between apo (a) and plasma lipid values (total cholesterol (TC), low density lipoprotein cholesterol (LDLc), high density lipoprotein cholesterol (HDLc), triglyceride. A significant association was noticed between apo (a) and apo B both in IDDM patients (r = 0.43; 0.02 < p < 0.05), and in controls (r = 0.83; p < 0.001). We conclude that apo (a) levels are higher in IDDM patients than in non-diabetic subjects, but they are not related to the degree of glycemic control. Apo (a) and apo B are significantly correlated, both of them being well-known atherogenic risk factors.
有人提出，胰岛素依赖型糖尿病（IDDM）患者的脂蛋白（a）-Lp（a）值较高，这可能是其动脉粥样硬化风险增加的原因，与非糖尿病患者相比。我们比较了在我们科室住院的1型糖尿病患者（n = 26）和罗马尼亚蒂米什瓦拉的非糖尿病患者（n = 20）的载脂蛋白（a）-（apo）（a）的血浆值。IDDM患者的apo（a）水平高于对照组[115（102 - 227）对58（51 - 106）U/l；中位数及95%置信区间]；（p = 0.0083）。糖尿病病程、血红蛋白A1（Hb A1）水平和体重指数（BMI）值与apo（a）浓度无显著相关性，而apo（a）与血脂值（总胆固醇（TC）、低密度脂蛋白胆固醇（LDLc）、高密度脂蛋白胆固醇（HDLc）、甘油三酯）之间未发现相关性。在IDDM患者（r = 0.43；0.02 < p < 0.05）和对照组（r = 0.83；p < 0.001）中均发现apo（a）与apo B之间存在显著相关性。我们得出结论，IDDM患者的apo（a）水平高于非糖尿病患者，但与血糖控制程度无关。Apo（a）和apo B显著相关，它们都是众所周知的动脉粥样硬化危险因素。
