Bégin R, Massé S, Dufresne A
Unité de recherche pulmonaire CHU, Sherbrooke, Québec, Canada.
Occup Environ Med. 1995 Nov;52(11):778-80. doi: 10.1136/oem.52.11.778.
In previous studies, a significant reduction in biological activity of quartz by the surface chemistry of aluminium was noted. Aluminium lactate inhalation one month after quartz exposure significantly suppressed silicosis. In a recent study, it was noted that aluminium inhalation failed to alter the silicosis process after disease was recognised by standard chest radiography in the first year after monthly treatment.
That study was extended with the same groups of sheep, the aluminium treated group received weekly aerosol of 100 mg of aluminium lactate for an additional two years. All sheep were evaluated at three-month intervals by chest radiography, lung function, and lung lavage.
The sheep with silicosis had significantly reduced lung functions, increased cellularity, phospholipids, and hyaluronan. These changes persisted for several years without significant differences between the silicotic sheep with or without the aluminium aerosol treatment.
Aluminium aerosol treatment of silicosis after radiographic recognition of disease and the end of exposure did not alter the disease process.
在先前的研究中，发现铝的表面化学性质可显著降低石英的生物活性。在接触石英一个月后吸入乳酸铝可显著抑制矽肺。在最近的一项研究中，发现每月治疗后第一年，在标准胸部X线片确诊疾病后，吸入铝未能改变矽肺进程。
该研究对相同组别的绵羊进行了扩展，铝治疗组在接下来的两年中每周接受100毫克乳酸铝气雾剂治疗。每隔三个月通过胸部X线片、肺功能和肺灌洗对所有绵羊进行评估。
患有矽肺的绵羊肺功能显著降低，细胞数量、磷脂和透明质酸增加。这些变化持续数年，接受或未接受铝气雾剂治疗的矽肺绵羊之间无显著差异。
在疾病经影像学确诊且接触结束后，用铝气雾剂治疗矽肺并未改变疾病进程。
