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镉以及YAP1和CAD1/YAP2基因对酿酒酵母中铁代谢的影响。

Effects of cadmium and of YAP1 and CAD1/YAP2 genes on iron metabolism in the yeast Saccharomyces cerevisiae.

作者信息

Lesuisse E, Labbe P

机构信息

Laboratoire de Biochimie des Porphyrines, Institut J. Monod, Université Paris, France.

出版信息

Microbiology (Reading). 1995 Nov;141 ( Pt 11):2937-43. doi: 10.1099/13500872-141-11-2937.

DOI:10.1099/13500872-141-11-2937
PMID:8535522
Abstract

Saccharomyces cerevisiae was more resistant to cadmium when the growth medium contained excess iron. Cadmium reduced the amount of iron taken up by cells during growth, and the cell ferrireductase activity was also strongly inhibited. These effects depended on the YAP1 and CAD1/YAP2 gene dosage. The growth rate of cells in iron-deficient conditions and their ferrireductase activity in the absence of added cadmium were also strongly affected by the dosage of YAP1 and CAD1/YAP2 genes. Our results suggest an indirect influence of these genes on iron metabolism, possibly via modification of the cell redox status.

摘要

当生长培养基中含有过量铁时，酿酒酵母对镉的耐受性更强。镉会减少细胞在生长过程中摄取的铁量，并且细胞铁还原酶活性也会受到强烈抑制。这些效应取决于YAP1和CAD1/YAP2基因的剂量。在缺铁条件下细胞的生长速率以及在不添加镉的情况下它们的铁还原酶活性也受到YAP1和CAD1/YAP2基因剂量的强烈影响。我们的结果表明这些基因可能通过改变细胞氧化还原状态对铁代谢产生间接影响。

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