使用特定免疫放射分析来确定早产新生儿胰岛素与葡萄糖的关系。
Use of specific immunoradiometric assay to determine preterm neonatal insulin-glucose relations.
作者信息
Hawdon J M, Hubbard M, Hales C N, Clark P M
机构信息
Institute of Child Health, Liverpool University.
出版信息
Arch Dis Child Fetal Neonatal Ed. 1995 Nov;73(3):F166-9. doi: 10.1136/fn.73.3.f166.
Abstract
Highly specific immunoradiometric assays were used to measure plasma concentrations of insulin, proinsulin, and 32-33 split proinsulin in neonates (n = 16). Neonatal plasma insulin concentrations were high relative to blood glucose concentrations and compared with adult insulin-glucose relations. Concentrations of proinsulin and 32-33 split proinsulin together accounted for 34-70% of the total concentration of insulin and pro-peptides. This study confirms the need to use a specific assay and neonatal reference data in the diagnosis of neonatal hyperinsulinism, and shows that neonatal pancreatic beta cell function may differ from that of older subjects.
摘要
采用高特异性免疫放射分析方法测定了16例新生儿血浆胰岛素、胰岛素原及32 - 33裂解胰岛素原的浓度。相对于血糖浓度而言，新生儿血浆胰岛素浓度较高，与成人胰岛素 - 血糖关系相比也是如此。胰岛素原和32 - 33裂解胰岛素原的浓度总和占胰岛素及胰岛素原总浓度的34% - 70%。本研究证实了在诊断新生儿高胰岛素血症时使用特异性检测方法及新生儿参考数据的必要性，并表明新生儿胰腺β细胞功能可能与年龄较大的个体不同。
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