Cosin-Aguilar J, Andres-Conejos F, Hernandiz-Martinez A, Solaz-Minguez J, Marrugat J, Bayes-De-Luna A
Centro de Investigacion, Hospital La Fe Valencia, Campanar, Valencia, Spain.
J Cardiovasc Risk. 1995 Aug;2(4):345-51.
Smoking has been related to coronary heart disease, and, in men, to sudden death. The results of a case-control study designed to assess the relationship between smoking and all causes of sudden and premature death are reported.
A questionnaire on the previous history and causes of death of all people buried in the Municipal Cemetery of Valencia (1986-1987) was administered to the relatives of the deceased. Among 4718 deaths, 284 victims of sudden death were identified, and 495 people who had not died suddenly were randomly sampled as controls.
The proportion of smokers among the women studied was extremely low in contrast to 58.9% of men in the sudden death study group and 59.2% of men in the non-sudden death study group who smoked. Smokers died on average 10 years younger than non-smokers in the sudden-death group (63.3 +/- 12.3 and 73.3 +/- 11.0 years respectively; P < 0.001), and 8 years earlier in the non-sudden death group (68.5 +/- 13.3 and 76.8 +/- 13.2 years, respectively; P < 0.001). A logistic regression model showed that smokers had an adjusted relative risk of 0.81 for sudden death compared with non-smokers (95% confidence interval [CI]: 0.45-1.46). Smokers 65 years of age or under had a 2.7 times greater risk (95% CI: 1.49-5.04) of premature death than non-smokers. Similar results were found in patients from the coronary- and cardiac-death subgroups.
Smoking is an independent risk factor for premature death but not for sudden death.
吸烟与冠心病相关，在男性中还与猝死有关。本文报告了一项病例对照研究的结果，该研究旨在评估吸烟与所有猝死和过早死亡原因之间的关系。
向瓦伦西亚市公墓（1986 - 1987年）所有埋葬者的亲属发放了一份关于死者既往病史和死亡原因的问卷。在4718例死亡病例中，确定了284例猝死受害者，并随机抽取495例未猝死的人作为对照。
在所研究的女性中，吸烟者的比例极低，而猝死研究组中58.9%的男性吸烟，非猝死研究组中59.2%的男性吸烟。猝死组中吸烟者的平均死亡年龄比不吸烟者早10年（分别为63.3±12.3岁和73.3±11.0岁；P<0.001），非猝死组中早8年（分别为68.5±13.3岁和76.8±13.2岁；P<0.001）。逻辑回归模型显示，与不吸烟者相比，吸烟者猝死的调整后相对风险为0.81（95%置信区间[CI]：0.45 - 1.46）。65岁及以下的吸烟者过早死亡的风险比不吸烟者高2.7倍（95%CI：1.49 - 5.04）。在冠心病和心脏死亡亚组的患者中也发现了类似结果。
吸烟是过早死亡的独立危险因素，但不是猝死的独立危险因素。
