类风湿关节炎患者外周血和滑液中单核细胞/巨噬细胞表型及细胞因子mRNA表达的变化
Changes in the phenotype of monocytes/macrophages and expression of cytokine mRNA in peripheral blood and synovial fluid of patients with rheumatoid arthritis.
作者信息
Highton J, Carlisle B, Palmer D G
机构信息
Department of Medicine, University of Otago Medical School, Dunedin, New Zealand.
出版信息
Clin Exp Immunol. 1995 Dec;102(3):541-6. doi: 10.1111/j.1365-2249.1995.tb03850.x.
Abstract
Data from a previous study suggested that peripheral blood monocytes in patients with rheumatoid arthritis (RA) may be activated. Therefore, in this study we sought further evidence of 'presynovial' activation of monocytes. Our results show that phenotypic changes are demonstrable in peripheral blood monocytes in patients with RA, including increased expression of CR3 (CD11b/CD18) and FcRI (CD64). However, changes are most extensive in synovial monocytes/macrophages and especially for HLA-DR and intercellular adhesion molecule-1 (ICAM-1) (CD54). We conclude that monocyte/macrophage activation is most evident within the joint, and that 'presynovial' changes occur but are of limited extent.
摘要
先前一项研究的数据表明，类风湿关节炎（RA）患者的外周血单核细胞可能被激活。因此，在本研究中，我们寻求单核细胞“滑膜前”激活的进一步证据。我们的结果显示，RA患者外周血单核细胞存在可证实的表型变化，包括CR3（CD11b/CD18）和FcRI（CD64）表达增加。然而，滑膜单核细胞/巨噬细胞中的变化最为广泛，尤其是HLA-DR和细胞间黏附分子-1（ICAM-1）（CD54）。我们得出结论，单核细胞/巨噬细胞激活在关节内最为明显，“滑膜前”变化确实存在，但程度有限。
相似文献
1
Changes in the phenotype of monocytes/macrophages and expression of cytokine mRNA in peripheral blood and synovial fluid of patients with rheumatoid arthritis.类风湿关节炎患者外周血和滑液中单核细胞/巨噬细胞表型及细胞因子mRNA表达的变化
Clin Exp Immunol. 1995 Dec;102(3):541-6. doi: 10.1111/j.1365-2249.1995.tb03850.x.
2
Quantification of macrophage cell surface molecules in rheumatoid arthritis.类风湿关节炎中巨噬细胞表面分子的定量分析。
Clin Exp Immunol. 1989 Jul;77(1):47-51.
3
Monocyte activation in rheumatoid arthritis: evidence for in situ activation and differentiation in joints.
Br J Rheumatol. 1990 Apr;29(2):84-8. doi: 10.1093/rheumatology/29.2.84.
4
Expression of Fcgamma and complement receptors on peripheral blood monocytes in systemic lupus erythematosus and rheumatoid arthritis.系统性红斑狼疮和类风湿关节炎患者外周血单核细胞上Fcγ和补体受体的表达
Rheumatology (Oxford). 2004 May;43(5):547-54. doi: 10.1093/rheumatology/keh112. Epub 2004 Jan 27.
5
Depletion of synovial macrophages in rheumatoid arthritis by an anti-FcgammaRI-calicheamicin immunoconjugate.一种抗FcγRI-卡奇霉素免疫偶联物对类风湿性关节炎滑膜巨噬细胞的清除作用
Ann Rheum Dis. 2005 Jun;64(6):865-70. doi: 10.1136/ard.2004.028845. Epub 2004 Nov 11.
6
Differential expression of chemokine receptors on peripheral blood, synovial fluid, and synovial tissue monocytes/macrophages in rheumatoid arthritis.类风湿关节炎患者外周血、滑液及滑膜组织中单核细胞/巨噬细胞趋化因子受体的差异表达
Arthritis Rheum. 2001 May;44(5):1022-32. doi: 10.1002/1529-0131(200105)44:5<1022::AID-ANR181>3.0.CO;2-N.
7
CD14+,CD16+ blood monocytes and joint inflammation in rheumatoid arthritis.类风湿关节炎中CD14+、CD16+血液单核细胞与关节炎症
Arthritis Rheum. 2002 Oct;46(10):2578-86. doi: 10.1002/art.10545.
8
Cytokines in chronic inflammatory arthritis. IV. Granulocyte/macrophage colony-stimulating factor-mediated induction of class II MHC antigen on human monocytes: a possible role in rheumatoid arthritis.慢性炎症性关节炎中的细胞因子。IV. 粒细胞/巨噬细胞集落刺激因子介导的人单核细胞上II类主要组织相容性复合体抗原的诱导：在类风湿性关节炎中的可能作用
J Exp Med. 1989 Sep 1;170(3):865-75. doi: 10.1084/jem.170.3.865.
9
Cells of the monocyte-macrophage series in peripheral blood and synovial fluid in inflammatory arthritis. A preliminary study of cellular phenotype.
Scand J Rheumatol. 1989;18(6):393-8. doi: 10.3109/03009748909102101.
10
Synovial fluid macrophages and blood monocytes differ in their response to IL-4.滑膜液巨噬细胞和血液单核细胞对白细胞介素-4的反应不同。
J Immunol. 1993 Sep 15;151(6):3370-80.
引用本文的文献
1
miR-155-overexpressing monocytes resemble HLAhighISG15+ synovial tissue macrophages from patients with rheumatoid arthritis and induce polyfunctional CD4+ T-cell activation.miR-155 过表达单核细胞类似于类风湿关节炎患者 HLAhighISG15+ 滑膜组织巨噬细胞，并诱导多功能 CD4+ T 细胞活化。
Clin Exp Immunol. 2022 Apr 4;207(2):188-198. doi: 10.1093/cei/uxab016.
2
Rheumatoid arthritis mediator CD18 expression by superantigen C in rats.超抗原C诱导大鼠类风湿性关节炎介质CD18的表达
Iran J Microbiol. 2019 Aug;11(4):337-344.
3
MicroRNA-155-at the Critical Interface of Innate and Adaptive Immunity in Arthritis.微小RNA-155——在关节炎中先天性免疫与适应性免疫的关键交汇点
Front Immunol. 2018 Jan 5;8:1932. doi: 10.3389/fimmu.2017.01932. eCollection 2017.
4
MicroRNA-155 contributes to enhanced resistance to apoptosis in monocytes from patients with rheumatoid arthritis.微小RNA-155有助于增强类风湿关节炎患者单核细胞对凋亡的抵抗能力。
J Autoimmun. 2017 May;79:53-62. doi: 10.1016/j.jaut.2017.01.002. Epub 2017 Jan 22.
5
FCGR3A-V158F polymorphism is a disease-specific pharmacogenetic marker for the treatment of psoriasis with Fc-containing TNFα inhibitors.FCGR3A-V158F多态性是使用含Fc的TNFα抑制剂治疗银屑病的疾病特异性药物遗传标记。
Pharmacogenomics J. 2017 Jun;17(3):237-241. doi: 10.1038/tpj.2016.16. Epub 2016 Apr 5.
6
Antibody induced CD4 down-modulation of T cells is site-specifically mediated by CD64(+) cells.抗体诱导的T细胞CD4下调由CD64(+)细胞位点特异性介导。
Sci Rep. 2015 Dec 16;5:18308. doi: 10.1038/srep18308.
7
The CD14+CD16+ inflammatory monocyte subset displays increased mitochondrial activity and effector function during acute Plasmodium vivax malaria.在间日疟原虫急性疟疾期间，CD14+CD16+炎性单核细胞亚群表现出线粒体活性增加和效应功能增强。
PLoS Pathog. 2014 Sep 18;10(9):e1004393. doi: 10.1371/journal.ppat.1004393. eCollection 2014 Sep.
8
Monocyte human leukocyte antigen-DR expression-a tool to distinguish intestinal bacterial infections from inflammatory bowel disease?单核细胞人类白细胞抗原-DR 表达——鉴别肠道细菌感染与炎症性肠病的工具？
Shock. 2013 Aug;40(2):89-94. doi: 10.1097/SHK.0b013e318299ebdd.
9
Evidence for somatic gene conversion and deletion in bipolar disorder, Crohn's disease, coronary artery disease, hypertension, rheumatoid arthritis, type-1 diabetes, and type-2 diabetes.在双相情感障碍、克罗恩病、冠心病、高血压、类风湿性关节炎、1 型糖尿病和 2 型糖尿病中发现体细胞基因转换和缺失的证据。
BMC Med. 2011 Feb 3;9:12. doi: 10.1186/1741-7015-9-12.
10
Depletion of synovial macrophages in rheumatoid arthritis by an anti-FcgammaRI-calicheamicin immunoconjugate.一种抗FcγRI-卡奇霉素免疫偶联物对类风湿性关节炎滑膜巨噬细胞的清除作用
Ann Rheum Dis. 2005 Jun;64(6):865-70. doi: 10.1136/ard.2004.028845. Epub 2004 Nov 11.
本文引用的文献
1
Vascularity of the early subcutaneous nodule of rheumatoid arthritis.
AMA Arch Pathol. 1953 Jun;55(6):475-95.
2
Modulation of monocyte activation in patients with rheumatoid arthritis by leukapheresis therapy.白细胞分离术治疗对类风湿关节炎患者单核细胞活化的调节作用。
J Clin Invest. 1993 Mar;91(3):862-70. doi: 10.1172/JCI116307.
3
MRP-8 and MRP-14, two abundant Ca(2+)-binding proteins of neutrophils and monocytes.MRP-8和MRP-14，中性粒细胞和单核细胞中两种丰富的钙结合蛋白。
J Leukoc Biol. 1993 Feb;53(2):197-204.
4
Synovial tissue macrophages and joint erosion in rheumatoid arthritis.类风湿关节炎中的滑膜组织巨噬细胞与关节侵蚀
Ann Rheum Dis. 1994 Jan;53(1):39-44. doi: 10.1136/ard.53.1.39.
5
Control of leukocyte integrin activation.白细胞整合素激活的调控
Am Rev Respir Dis. 1993 Dec;148(6 Pt 2):S55-9. doi: 10.1164/ajrccm/148.6_Pt_2.S55.
6
Evidence in support of a self-perpetuating HLA-DR-dependent delayed-type cell reaction in rheumatoid arthritis.支持类风湿关节炎中存在一种自我持续的依赖HLA - DR的迟发型细胞反应的证据。
Proc Natl Acad Sci U S A. 1982 Jun;79(11):3632-6. doi: 10.1073/pnas.79.11.3632.
7
Immune interferon induces the receptor for monomeric IgG1 on human monocytic and myeloid cells.免疫干扰素可诱导人单核细胞和髓样细胞上单体IgG1的受体。
J Exp Med. 1983 Oct 1;158(4):1092-113. doi: 10.1084/jem.158.4.1092.
8
Rheumatoid arthritis: a disease of T-lymphocyte/macrophage immunoregulation.类风湿性关节炎：一种T淋巴细胞/巨噬细胞免疫调节疾病。
Lancet. 1981 Oct 17;2(8251):839-42. doi: 10.1016/s0140-6736(81)91107-7.
9
A mononuclear phagocyte subset associated with cell necrosis in rheumatoid nodules: identification with monoclonal antibody 5.5.类风湿结节中与细胞坏死相关的单核吞噬细胞亚群：用单克隆抗体5.5鉴定
Clin Immunol Immunopathol. 1987 Oct;45(1):17-28. doi: 10.1016/0090-1229(87)90107-3.
10
The human mononuclear phagocyte high-affinity Fc receptor, FcRI, defined by a monoclonal antibody, 10.1.由单克隆抗体10.1所界定的人类单核吞噬细胞高亲和力Fc受体FcRI
Eur J Immunol. 1987 Oct;17(10):1453-9. doi: 10.1002/eji.1830171011.
Zotero 插件