Koga T, Yamato T, Ikeda I, Sugano M
Department of Food and Nutrition, Nakamura Gakuen University, Fukuoka, Japan.
Lipids. 1995 Oct;30(10):935-40. doi: 10.1007/BF02537485.
Randomization of partially hydrogenated corn oil containing approximately 45% of trans octadecenoic acid only slightly, but not significantly, increased the lymphatic fatty acid absorption in rats. No effect of randomization was observed on cholesterol absorption. When rats were fed these fats at the 8.8% level (with 1.2% safflower oil) for three weeks, the concentrations of serum cholesterol, and serum and liver phospholipid were significantly higher in randomized fat than in control fat, which was composed of 9% high-oleic safflower oil and 1% palm oil. Liver cholesterol tended to be higher in randomized fat. In contrast, nonrandomized fat was not hyperlipidemic compared to control fat. Although the fatty acid composition of liver phospholipids suggested a possible interference of trans fatty acid with the metabolism of linoleic acid to arachidonic acid, there was no effect of randomization. In the two hydrogenated fat groups, trans octadecenoic acid was incorporated and distributed similarly in adipose tissue triacylglycerol. These observations indicated that randomization of partially hydrogenated fat is not beneficial to various lipid parameters in rats.
随机给予含有约45%反式十八碳烯酸的部分氢化玉米油，仅轻微但不显著地增加了大鼠的淋巴脂肪酸吸收。未观察到随机化对胆固醇吸收有影响。当大鼠以8.8%的水平（含1.2%红花油）喂食这些脂肪三周时，随机化脂肪组的血清胆固醇、血清和肝脏磷脂浓度显著高于对照脂肪组，对照脂肪组由9%的高油酸红花油和1%的棕榈油组成。随机化脂肪组的肝脏胆固醇有升高趋势。相比之下，与对照脂肪相比，非随机化脂肪不会导致血脂升高。尽管肝脏磷脂的脂肪酸组成表明反式脂肪酸可能干扰亚油酸向花生四烯酸的代谢，但随机化没有产生影响。在两个氢化脂肪组中，反式十八碳烯酸在脂肪组织三酰甘油中的掺入和分布相似。这些观察结果表明，部分氢化脂肪的随机化对大鼠的各种脂质参数并无益处。
