Walsh S V, Egan L J, Connolly C E, Stevens F M, Egan E L, McCarthy C F
Department of Histopathology, University College Hospital, Galway, Ireland.
Mod Pathol. 1995 Sep;8(7):753-7.
The Epstein-Barr virus has been implicated in the etiology of endemic Burkitt's lymphoma, post-transplant lymphoma, large-cell anaplastic CD30 (Ki-1)-positive lymphoma, and in many T-cell lymphomas. A recent report has found Epstein-Barr virus genome in association with 4 of 11 cases (36%) of enteropathy-associated T-cell lymphoma. In a retrospective study, we have characterized 22 consecutive cases of enteropathy-associated T-cell lymphoma from the West of Ireland where celiac disease is endemic. All cases were immunophenotyped with T- and B-cell markers including the anaplastic large-cell lymphoma marker CD30 or Ki-1. Nineteen cases were studied for latent membrane protein expression and 16 for Epstein-Barr virus small RNAs by in situ hybridization using EBER oligonucleotides on routinely processed sections. Only 1 of 16 cases (6%) showed Epstein-Barr virus in tumor cells and no cases stained with latent membrane protein. Eight of 22 cases (36%) including the EBER-positive case were positive for CD30. These results suggest that the Epstein-Barr virus does not commonly play a role in the pathogenesis of enteropathy-associated T-cell lymphoma from this area.
爱泼斯坦-巴尔病毒与地方性伯基特淋巴瘤、移植后淋巴瘤、大细胞间变性CD30（Ki-1）阳性淋巴瘤以及许多T细胞淋巴瘤的病因有关。最近的一份报告发现，在11例肠病相关T细胞淋巴瘤病例中有4例（36%）与爱泼斯坦-巴尔病毒基因组相关。在一项回顾性研究中，我们对来自爱尔兰西部乳糜泻流行地区的22例连续的肠病相关T细胞淋巴瘤病例进行了特征分析。所有病例均用T细胞和B细胞标志物进行免疫表型分析，包括间变性大细胞淋巴瘤标志物CD30或Ki-1。19例病例研究了潜伏膜蛋白表达，16例通过在常规处理切片上使用EBER寡核苷酸进行原位杂交检测爱泼斯坦-巴尔病毒小RNA。16例病例中只有1例（6%）在肿瘤细胞中显示有爱泼斯坦-巴尔病毒，且没有病例潜伏膜蛋白染色阳性。22例病例中有8例（36%）包括EBER阳性病例CD30呈阳性。这些结果表明，爱泼斯坦-巴尔病毒在该地区肠病相关T细胞淋巴瘤的发病机制中通常不起作用。
